By applying an MR approach in the EHR, we replicated the association between HMGCR and risk of type 2 diabetes and found that every 10-mg/dL estimated decrease of the LDL-C level was associated with an approximately 9% increase in the risk of type 2 diabetes—an estimate comparable with a previous MR report.16 However, the cardiovascular benefits of statins in clinical practice outweigh the small increased risk of type 2 diabetes. This evidence concerns the gene HMGCR and type 2 diabetes mellitus.