We calculated an HMGCR GRS for 30 444 unrelated adults of European ancestry in the eMERGE cohort (Table 1) and found that, for a 10-mg/dL HMGCR GRS–estimated decrease in the LDL-C level, the OR of having a diagnosis of hypercholesterolemia was 0.85 (95% CI, 0.77-0.92; P = 2.25 × 10−4) (eTable 2 in the Supplement). The gene discussed is HMGCR; the disease is familial hypercholesterolemia.