For a 10-mg/dL HMGCR GRS–estimated decrease of the LDL-C level, the OR of having the PheCode of hypercholesterolemia was 0.91 (95% CI, 0.85-0.98; P = .009) (eTable 2 and the eFigure in the Supplement). Here, HMGCR is linked to familial hypercholesterolemia.