Calycosin significantly increased the expression of E-cadherin (epithelial cell biomarker) and decreased the expression levels N-cadherin and Vimentin (mesenchymal cell biomarkers) as well as CD147, MMP-2, and MMP-9 (pro-metastatic proteins) in the breast cancer cells (Figure 5A). Here, MMP2 is linked to breast carcinoma.