By analyzing transcriptomics and proteomics data, we identified aldehyde dehydrogenase RALDH1 (ALDH1A1, alternatively known as retinaldehyde dehydrogenase 1 or RALDH1) gene as a mediator related to both liver physiology and hypertension-NAFLD interaction, which has also been identified as differently expressed gene of a high blood pressure vs normal blood pressure mice gene series. Here, ALDH1A1 is linked to metabolic dysfunction-associated steatotic liver disease.