KEGG enrichment indicated core genes are enriched in fluid shear stress and atherosclerosis, AGE-RAGE signaling pathway in diabetic complications, renin secretion, vascular smooth muscle contraction, nonalcoholic fatty liver disease, fatty acid degradation, hepatocellular carcinoma, Insulin resistance, adipocytokine signaling pathway, renin-angiotensin system, retinol metabolism and p53 signaling pathway (Figure 4F). Here, REN is linked to hepatocellular carcinoma.