The current study demonstrates that MMPs including MMP-2, MMP-9, MMP-11, and MMP-19 levels are increased in patients suffering from colon cancer which is concurrent with the studies of Yang et al., 2014; Langenskiold et al., 2005, Xu and Xu, 2014, and Sena et al., 2012 [63–66]. Here, MMP2 is linked to malignant colon neoplasm.