The levels of all MMPs including MMP-2, MMP-9, MMP-11, and MMP-19 were reported significantly high in patients with colon cancer [MMP-2 (19.58 ± 1.58 pg/ml), MMP-9 (84.26 ± 4.26 pg/ml), MMP-11 (51.26 ± 1.58), and MMP-19 (46.35 ± 4.19 pg/ml)] compared to their MMP profile [MMP-2 (9.26 ± 1.44 pg/ml), MMP-9 (19.65 ± 6.56 pg/ml), MMP-11 (27.59 ± 3.26), and MMP-19 (16.35 ± 3.33 pg/ml)] in normal individuals. This evidence concerns the gene MMP11 and malignant colon neoplasm.