Analysisof tissue micro-array of the patients revealed thatBRMS1 was considerably down-regulated in gliomacells in comparison with the normal astrocytes.Additionally BRMS1 over-expression could inhibitmigration and invasion of glioma cells via suppressingMMP-2 , NF-κB and uPA (21). The gene discussed is NFKB1; the disease is central nervous system cancer.