However, we found that miR-373could inhibit cell proliferation and apoptosis via regulation of SIRT1/PGC-1α/NRF2 axis inpancreatic cancer, which was consistent with the report of Nakata et al. (13) indicatingthat miR-373 was down-regulated in PC and suppressed invasion of tumorcells. The gene discussed is PPARGC1A; the disease is pachyonychia congenita.