EGFR signaling is important in driving high regulatory T cell (Treg) infiltration, despite low CD8+ effector T cell infiltration in EGFR‐mutated lung adenocarcinomas, via CCL22 upregulation through JNK/cJun and CXCL10 downregulation mediated by IRF1. Here, EGFR is linked to lung adenocarcinoma.