The results demonstrated that down‐regulation of KISS1 by specific siRNA led to increased proliferation of melanoma cells while simultaneous transfection of Let‐7i and KISS1 inhibitor attenuated KISS1 inhibitor‐induced proliferation (Figure 7A‐C, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001). Here, KISS1 is linked to melanoma.