BRCA1 and cancer: The germline variant and somatic mutation frequencies differed across cancer types; ovarian cancer (OV) showed the highest frequency (17.6%; cases may carry multiple DDR variants) of carrying germline DDR variants, predominantly affecting BRCA1/2, while uterine corpus endometrial carcinoma (UCEC) had the highest frequency (20.7%; cases may carry multiple DDR mutations) of somatic DDR mutations (Figure 1A).