We investigated the distribution of immune signatures in COADREAD patients stratified by MLH1 deficiency and neoantigen load, including MLH1 deficiency/high neoantigen load, MLH1-WT/high neoantigen load, MLH1 deficiency/low neoantigen load, and MLH1-WT/low neoantigen load. This evidence concerns the gene MLH1 and hyperinsulinemic hypoglycemia, familial, 4.