BRCA1 and gastric adenocarcinoma: However, germline variants of BRCA2 and PALB2 were significantly associated with elevated TMB in OV (FDR = 0.0034) and stomach adenocarcinomas (STAD, FDR = 0.032), respectively, while germline BRCA1 variants showed only a non-significant trend for association with higher TMB in OV (FDR = 0.061, p = 0.017).