Using these tools, we created 2 murine models of Mlh1-deficient HCC: the non-immunogenic MYC-luc;sg-p53;sg-Mlh1 (Mycluc p53 MLH1) and the immunogenic counterpart MYC-lucOS;sg-p53;sg-Mlh1 (MyclucOS p53 MLH1), which expresses the 3 antigens (Figure 6I). This evidence concerns the gene TP53 and hepatocellular carcinoma.