Somatic mutations of MMR genes (PMS2, MLH1, and MSH2) and DNA damage sensors (ATR, ATM, and CHEK2) and ERCC2 were associated with higher TMB in UCEC, skin cutaneous melanoma (SKCM), BRCA, kidney renal papillary cell carcinoma (KIRP), colorectal adenocarcinoma (COADREAD), and urothelial bladder carcinoma (BLCA) (FDR < 0.05; Figure 2A; Table S3). The gene discussed is CHEK2; the disease is cutaneous melanoma.