,5 Dravet syndrome is caused mainly by sodium channel gene SCN1A variants, but due to the use of massively parallel sequencing technologies, a significant number of variants in other genes such as GABRs have been found to arise de novo in EE cases including Dravet syndrome patients.5–9. The gene discussed is SCN1A; the disease is encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy.