In contrast, there are epilepsy syndromes associated with variants in GABRA1 and GABRB3 (IS), but not with GABRG2, with GABRB3 (LGS) but not with GABRA1 or GABRG2 and with GABRA1,2,5 and GABRB2,3 [early onset EE (EOEE)] but not with GABRG2. Here, GABRB3 is linked to epilepsy syndrome.