PLAU and atherosclerosis: uPA is often inextricably linked to a unique uPA cell surface receptor (uPAR66) where it can perform various functions, some linked to cell-surface plasminogen activation and others to intracellular signaling,67 particularly in the context of malignancy as recently reviewed.68 uPA and uPAR have also been associated with cell adhesion,69,70 neointimal formation, and atherosclerosis.71