PDCD4 and hepatocellular carcinoma: The tumor-promotive role of SNHG1 in HCC has also been evidenced by several recent research studies.29, 30, 31, 32 These studies also demonstrated that PDCD4, Akt pathway, miR-21, and miR-195 may be downstream signaling molecules of SNHG1-mediated promotion of HCC progression.