AKT1 and cancer: For instance, PI (3,4,5) P3, which is synthesized by phosphatidylinositol-3 kinase, promotes cell survival and proliferation by activating the protein kinase B/Akt pathway [22, 23]; lysophosphatidic acid (LPA), which transmits signals through G-protein coupled receptors, thereby promoting the invasion of cancer cells [24, 25]; furthermore, prostacyclin catalyzed by cyclooxygenase promotes tumor migration [26, 27].