This is in contrast with early studies where infusing rHDL in cholesterol-fed rabbit models attenuated development of atherosclerosis [8, 9] and in Apoe-deficient mice where single infusions of HDL containing ApoA-I (apolipoprotein A-I)Milano and dipalmitoyl phosphatidylcholine reduced plaque size, lipid, and macrophage content in atherosclerotic plaques [50]. The gene discussed is APOE; the disease is atherosclerosis.