ABCA1 and diabetes mellitus: Furthermore, ApoA-I protected against diabetes by reducing stress-induced pancreatic β-cell apoptosis and increasing insulin secretion [16], and HDL attenuated islet cell inflammation in type 2 diabetes via ATP-binding cassette transporter-A1 and ATP-binding cassette transporter-G1 (ABCA1 and ABCG1) [16, 17].