This study for the first time showed that RHPN1-AS1, LINC01134, NRAV, CMB9-22P13.1, MKLN1-AS, and MAPKAPK5-AS1 were overexpressed in HCC, and a higher expression of these lncRNAs was observed in advanced-stage HCC samples as compared to early-stage HCC samples. This evidence concerns the gene RHPN1 and hepatocellular carcinoma.