To determine the potential mechanisms of GC action and explore the regulatory effect of GC on KCs in the progression of NASH, we used a high-fat and high-cholesterol (HFHC) (high-trans fat, high-cholesterol, and high-bile-salt feed) diet and high-sugar drinking water to induce NASH in a C57BL/6 mice model and RAW264.7 cells. The gene discussed is GC; the disease is metabolic dysfunction-associated steatohepatitis.