GPT and fatty liver disease: In the present study, we found that GC treatment in mice exposed to HFHC diet containing cholesterol, choline, and high-sugar drinking water resulted in the dramatic attenuation of steatohepatitis, including repressed liver steatosis, decreased plasma ALT and AST, and suppression of hepatic inflammation, collagen deposition, and nutritional fibrosis, compared with mice exposed to a control diet.