HCoV-NL63, an α-CoV, which leads to common cold symptoms, may be essential to follow as, in contrast to other α-CoVs, which rely on the CD13 (aminopeptidase) receptor for entry into host cells, it has been shown to lead to frequent infection in humans and utilizes the ACE2 receptor, and so may only require minor alterations to become more virulent (227, 287, 288). Here, ANPEP is linked to infection.