SIRT3 and cardiovascular disorder: By reviewing the studies of Sirt3 and other cardiovascular diseases, we found that in H9C2 cardiomyocytes with Sirt3 overexpression, the opening of the mitochondrial permeability transition pore (MPTP) was restricted due to the deacetylation of CYPD, and the death of cardiomyocytes caused by oxidative damage was reduced (30).