SIRT3 and heart failure: In addition, the expression level of Sirt3 mRNA in peripheral blood of patients with heart failure was significantly lower than that of the control group, and it was negatively correlated with blood MDA, 80HdG content, LAD, LVEDD, and LVEDV and positively correlated with SOD content and LVEF, which suggests that when heart failure occurs, the decrease in Sirt3 level may be involved in oxidative stress damage, especially mitochondrial damage and the process of heart remodeling (31).