In addition, the Li et al. (69) built ultrasound/optical dual-modality probe (Cy5.5-anti-OPN-PEG-PLA-PFOB, denoted as COP-NPs), which uses OPN targeted nanoparticles for the molecular imaging of foam macrophage cells, could be a promising tool for identifying the molecular characteristics of mice at high-risk of atherosclerosis. The gene discussed is SPP1; the disease is atherosclerosis.