INS and obesity due to melanocortin 4 receptor deficiency: So far, results of these studies are inconclusive: Tascilar reported reduced HVR in children with obesity as compared to their age-matched controls (13), Quilliot noticed no significant difference in terms of BMI, but confirmed the negative influence of insulin resistance and age on HRV (28), Rabbia attributed the discrepancy in the degree of RSA among pediatric patients with excessive body mass to the duration of obesity (29).