Two meta analyses of genome wide association studies for AD risk factors have implicated enhanced expression of the 3-O HS sulfotransferase gene Hs3st1 as an AD risk factor, supporting existing observations on the role of 3-O sulfated HS in tau protein uptake and phosphorylation (Witoelar et al., 2018; Schwartzentruber et al., 2021). This evidence concerns the gene HS3ST1 and Alzheimer disease.