RHO and neoplasm: DLC-1 is a GTPase-activating protein that targets Rho (Kim et al., 2007), and as a tumor suppressor, DLC-1 is not only involved in hepatocarcinogenesis, but also inhibits the cancer progression and oncogenic autophagy of hepatocellular carcinoma (Wu et al., 2018) (Zhou et al., 2004).