Cell leading edge (Perike et al., 2014), focal adhesion (Gu and Zhou, 2018), cell adhesion molecule binding (Du et al., 2018), protein serine/threonine kinase activity (Pruksakorn et al., 2018), phospholipid-binding (Jiang et al., 2018), ATPase activity (Meszaros and Karin, 1995), and protein tyrosine kinase activity (Kostas et al., 2018) have been previously shown to be associated with osteosarcoma development and metastasis. The gene discussed is AKT1; the disease is osteosarcoma.