TMEFF2 and cancer: Lofton-Day C. et al. detected the expression of methylated TMEFF2, NGFR, and SEPT9 genes in plasma samples of CRC patients and healthy controls using the reverse transcription polymerase chain reaction, and the results confirmed that the methylated SEPT9 gene was highly expressed in cancer tissues and the peripheral blood of CRC patients (Lofton-Day et al., 2008).