At present, studies about mSEPT9 mainly focus on screening, diagnosis, prognosis, and correlation analysis with histopathology, and Shen N et al. reported that the hypermethylation of SEPT9 associated with worse overall survival (OS) and disease-free survival (DFS) (Shen et al., 2019), but there were no systematic reports about the relationship between mSEPT9 with specific molecular characteristics of CRC and the prognosis value of adjuvant chemotherapy or recurrence. This evidence concerns the gene SEPTIN9 and colorectal carcinoma.