TNF and cardiovascular disorder: Global cardiometabolic risk is another framework used to discuss one's comprehensive cardiometabolic risk, which includes the presence of traditional risk factors of cardiovascular disease (e.g., hypertension and high cholesterol), the metabolic syndrome criteria (e.g., waist circumference, and triglycerides), and inflammatory cytokines and adipokines (e.g., tumor necrosis factor alpha [TNF-α], low adiponectin) (11, 12).