Available research indicated that certain genetic variants such as the fat mass and obesity-associated (FTO), MC4R, APOE, and fibroblast growth factor −21 (FGF21) (5–10), which were associated with adiposity, may influence food preference patterns such as increased intake of sugar and carbohydrate consumption (11–13), total energy intake, and preferences of macronutrients (5–10). This evidence concerns the gene FGF21 and obesity due to melanocortin 4 receptor deficiency.