AKT1 and retinoblastoma: In addition to non-coding RNAs, cyclin-dependent kinase regulatory subunit 1B (CKS1B) downregulation hinders the proliferation, migration, and angiogenesis of retinoblastoma cells through the MEK/ ERK signaling pathway, and an anti-oncogene scavenger receptor class A member 5 (SCARA5) was reported to prevent the proliferation and migration of retinoblastoma cell lines by suppressing the PI3K/AKT signaling pathway (49, 50).