In addition, with the increasing attention having been paid to the clinical use of anti-VEGF (vascular endothelial growth factor) agents in the patients with eye disease (43), a retrospective review suggested that intravitreal anti-VEGF contributed to a globe salvage rate of 51%, indicating the potential of intravitreal anti-VEGF in the conservative treatment of retinoblastoma (44). The gene discussed is VEGFA; the disease is eye disorder.