Accordingly, the consensus guidelines of the European Crohn's and Colitis Organization (ECCO) (3) and the Asian Organization for Crohn's and Colitis (AOCC) and the Asia Pacific Association of Gastroenterology (APAGE) (4) recommend screening for TB and treating latent TB infection (LTBI) before the initiation of TNF inhibitor therapy. This evidence concerns the gene TNF and tuberculosis.