The levels of SCr and cystatin C in patients with glomerular sclerosis were higher than those in patients without glomerular sclerosis, which were 99.80 (86.47, 148.60) vs. 75.53 (67.19, 89.83) (P = 0.005), 1.34 (0.89, 1.86) vs. 0.99 (0.80, 1.20) (P = 0.014), respectively. The gene discussed is CST3; the disease is glomerulosclerosis.