Similar to our speculations on COL14A1, there may be analogous paracrine effects by fibroblast-generated COL16A1, albeit in reverse directions: Loss of fibroblast-generated COL14A1 on the one hand, as well as induction of COL16A1 deposition by fibroblasts on the other, may lead to increased cell proliferation and aberrant differentiation of adjacent epithelial cells and thus contribute to tumorigenesis and tumour invasion. The gene discussed is COL14A1; the disease is neoplasm.