As shown in Figure 6C, the ECM genes, such as Dcn, Mgp, Fn1, and Bgn were markedly increased in EndMT+ cell, and DDC feeding further enhanced the expression of Dcn and Fn1, in line with a prior study identifying that ECs transform toward a mature fibroblast-like phenotype during atherosclerosis progression (Souilhol et al., 2018). Here, DCN is linked to atherosclerosis.