Hyperglycemia, insulin resistance, lipid metabolism defects and oxidative stress up-regulate the production of advanced glycation end-products (AGEs) and Ang II, which in turn induce mitochondrial dysfunction in cardiomyocytes and ECs (Tan et al., 2002; Dikalov and Nazarewicz, 2013; Yan et al., 2014; Brunvand et al., 2017). Here, AGT is linked to Hyperglycemia.