LAMP3 and neoplasm: While some earlier reports describe the presence of TLS-associated cell types such as high endothelial venules (Dieu-Nosjean et al., 2008) and LAMP3+ mature dendritic cells (Ladányi et al., 2007) in primary human melanomas, a systematic analysis of numbers, areas, localization and maturation states of TLS at different tumor stages is still lacking.