Only the lncRNA PVT1 has been reported to regulate the balance of iron metabolism in hepatocellular carcinoma via PVT1/miR-150/HIG2 axis (Xu et al., 2018), and regulate ferroptosis in acute ischemic stroke (AIS) through miR-214-mediated TFR1 and p53 expression (Lu et al., 2020). This evidence concerns the gene TP53 and hepatocellular carcinoma.