CD19 and diffuse large B-cell lymphoma: Because of the striking clinical efficacy of CAR-T cells, Kymriah and Yescarta, two types of anti-CD19 CAR-T cells, have been approved by the U.S. Food and Drug Administration (FDA) to treat pediatric/young adult B lymphoblastic leukemia (B-ALL) and adult diffuse large B cell lymphoma (DLBCL).