However, when fed with an HFD, LAMTOR1 MKO mice showed a significant decrease in the body weight and white adipose tissue (WAT) mass, as well as a smaller liver (vs. WT mice), suggesting the macrophage-specific depletion of LAMTOR1 was able to prevent HFD-induced obesity (Figures 2A–D). This evidence concerns the gene LAMTOR1 and obesity due to melanocortin 4 receptor deficiency.