We down-regulated the expression of DCBLD2 in colorectal cancer cells, and the mRNA and protein levels of transcription factors upstream of EMT signal, ZEB1, ZEB2 and SNAIL significantly decreased, which suppress epithelial genes and activate a mesenchymal expression program (Lin et al., 2013; Kotiyal and Bhattacharya, 2016). This evidence concerns the gene SNAI1 and colorectal cancer.