However, mTOR activation is postulated to contribute to posttraumatic maladaptive hippocampal plasticity and cognitive impairment associated with posttraumatic epilepsy, a premise supported by improved outcomes associated with administration of the mTOR inhibitor rapamycin (Park et al., 2012; Guo et al., 2013; Butler et al., 2015; Rozas et al., 2015). The gene discussed is MTOR; the disease is Cognitive impairment.