García-Recio et al. (2016) screened two aptamers, called apMNK2F and apMNK3R. The selected aptamers were highly specific for MNK1. ApMNK2F and apMNK3R bind with MNK1 to produced significant translational inhibition, inhibiting tumor cell proliferation, migration, and colony formation in MDA-MB231 breast cancer cells (García-Recio et al., 2016). This evidence concerns the gene MKNK1 and breast cancer.