SLC5A2 and hydrops fetalis: Another study, using the same AA-induced HF model, shows that treatment with empagliflozin, a sodium-glucose cotransporter 2 (SGLT2) inhibitor, used in the treatment of type 2 diabetes and HF, attenuates cardiac morphological changes, and reduces the expression of BNP and ANP as well as mortality of embryonic zebrafish (Shi et al., 2017).