NPPB and cardiac hypertrophy: In embryonic zebrafish, knockdown of ndufa7 and hhatla (HHATL ortholog in zebrafish) with morpholinos results in impaired contractility, cardiac hypertrophy, and increased expression of the hypertrophy markers nppa (ANP), nppb (BNP), and vmhc (ventricular myosin heavy chain) (Shi et al.,2020a,b).