Another study, using the same AA-induced HF model, shows that treatment with empagliflozin, a sodium-glucose cotransporter 2 (SGLT2) inhibitor, used in the treatment of type 2 diabetes and HF, attenuates cardiac morphological changes, and reduces the expression of BNP and ANP as well as mortality of embryonic zebrafish (Shi et al., 2017). The gene discussed is NPPB; the disease is hydrops fetalis.