Interestingly, deletion of Kif3a, Ift20, and Ift88 in Pkd1 and Pkd2 conditional knockout mice ablated or shortened primary cilia and markedly attenuated the ADPKD cystic phenotype (Ma et al., 2013; Viau et al., 2018; Shao et al., 2020). This evidence concerns the gene PKD1 and autosomal dominant polycystic kidney disease.