Further analysis of tumor-infiltrating Cd4-1 + cells showed that these cells expressed higher levels of gata3 and il-4/13a but not il-4/13b, indicating the presence of a specific subset of Th2 cells in the TME of melanoma, which are absent in normal mucosal environments such as the gills (Dee et al., 2016). The gene discussed is IL4; the disease is melanoma.