Transforming growth factor-b1 (TGF-b1) signaling in hepatic stellate cells (HSCs) plays a crucial role in liver fibrosis by initiating profibrotic signaling in HSCs and collagen synthesis (Ghafoory et al., 2018), but the source of TGF-b1 is unclear. This evidence concerns the gene TGFB1 and Hepatic fibrosis.