TOR1A and Dystonia: It is known from a mouse model of DYT-TOR1A dystonia that the TOR1A mutation leads to a change in the calcium dynamics and to an impairment of striatal D2 receptor-dependent control of GABAergic activity resulting in an increased GABAergic transmission in medium spiny neurons and fast-spiking interneurons (Sciamanna et al., 2009; Iwabuchi et al., 2013).