BCL2 and Miyoshi myopathy: BMSC-derived exosomes activate several pathways including p38, p53, c-Jun N-terminal kinase, and AKT pathways related to survival, promoting MM cell survival and chemoresistance in vivo by increasing antiapoptotic protein Bcl-2 and reducing the cleavage of caspase-9, caspase-3 (Wang et al., 2014).