ALOX15 and gastric cancer: Further, it has been demonstrated that cisplatin and paclitaxel treatment of gastric cancer promoted the secretion of miRNA 522 from CAFs, with the activation of ubiquitin-specific protease 7 (USP7)/heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1) axis, resulting in arachidonate lipoxygenase 15 (ALOX15) inhibition and ultimately decreased chemo-sensitivity (Zhang H. et al., 2020).