In gastric cancer treated with 5-fluorouracil (5-FU), transformation of M2-type TAMs was ascribed to accumulation of reactive oxygen species (ROS), activating hypoxia-inducible factor 1α (HIF-1α) signaling, driving the expression of high-mobility group box 1(HMGB1). The gene discussed is HMGB1; the disease is gastric cancer.