Stromal cell derived factor-1 (SDF-1) was found to be overexpressed in CAFs and played an essential role in tumor cell metastasis and chemoresistance by activating its receptor chemokine receptor 4 (CXCR4) (Orimo and Weinberg, 2006; Teng et al., 2016; Zou et al., 2017). This evidence concerns the gene CXCL12 and neoplasm.