SOD1 and amyotrophic lateral sclerosis: Numerous studies conducted in mice with the Gly93Ala mutation in the SOD1 gene (SOD1-G93A mice), which leads to the development of ALS symptoms (progressive loss of muscle strength, onset of the disease at about 5 months, and a life span of about 6 months) (Julien and Kriz, 2006), have demonstrated that BM-MSCs induce important therapeutic effects (Zhao et al., 2007; Vercelli et al., 2008; Zhou et al., 2013).