In NAFLD patients, logistic regression yielded the following independent predictors of frailty (LFI > 4.5): male sex (OR = 0.31, 95% CI 0.12–0.816), BMI (OR = 1.16, 1.04–1.28), MAC (OR = 0.79, 0.68–0.91), and CRP (OR = 1.04, 1.01–1.06). This evidence concerns the gene CRP and metabolic dysfunction-associated steatotic liver disease.