During acute infections, such as Escherichia coli infection may induce the haemolytic uremic syndrome, triggering the formation of microvascular thrombi mediated by Von Willebrand Factor (VWF) (Zheng and Sadler, 2008; Pillai et al., 2016; Ueda et al., 2017). The gene discussed is VWF; the disease is escherichia coli infection.