In in vivo model, when athymic female nude mice implanted with HCT-116 p53 WT and p53-null cells into both flanks, and only one flank was irradiated, the growth of non-irradiated WT tumours was inhibited to a larger extent (ie anti-tumour abscopal effect) due to the apoptotic pathway activation, compared to non-irradiated p53-null tumours (51). Here, TP53 is linked to neoplasm.