METTL3 and METTL14 decrease the RNA level of tripartite motif 7 (TRIM7), while the upregulation of TRIM7 can increase metastasis and the chemoresistance of osteosarcoma by regulating ubiquitination of breast cancer metastasis suppressor 1 (BRMS1) (69). Here, METTL3 is linked to osteosarcoma.